Junior Scientist Translational Biology (CNS Biomarkers)

Seuss+

We are looking for a highly motivated and inquisitive (Junior) Scientist to support the development of (novel) translational efficacy measures

  • Biotechnology
  • Junior Scientist
  • Translational Biology
Junior Scientist Translational Biology (CNS Biomarkers)

Our client is dedicated to bringing innovative therapies or unmet medical needs to patients. In doing so each function is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) by recognizing the sense of urgency in areas of high medical need.
 
Purpose of the role
We are looking for a highly motivated and inquisitive (Junior) Scientist to support the development of (novel) translational efficacy measures (biofluid and imaging biomarkers) of gene therapies for CNS disorders.  
 
Place in the Organization
The position is based in the Research Department (Amsterdam), within the Translational Biology group. The key activities of the group are to develop novel biomarker measures to show efficacy of our gene therapy approaches in the clinic, and to understand the underlying biology of these measures. To this end, novel methods, tailored to the known mechanism-of-action of each given gene therapy approach, are needed. These measures are tested in both in vitro and in preclinical studies.
 
Key result areas (major duties, accountabilities, and responsibilities) 
  • Develops new analytical methods (inhouse or outsourced) for detection of biomarkers in pre-clinical and clinical samples
  • Participates in study design and implementation of dedicated biomarker studies in pre-clinical models (in vitro and in vivo)
  • Participates directly in experimental work planned together with key team members
  • (Partly) supervises and plans the work of technicians to guarantee the on-time execution and progress of research projects
  • Brings up his/her ideas about the line of research and, upon mutual agreement, implements the new ideas and concepts, disseminates, and reports the results
  • Plans his/her own work under supervision, sets priorities and timelines and adheres to these timelines
  • Is quality orientated (i.e. detail and data critical) and he/she evaluates his/her own behavior and corrects him/herself if needed. He/she proposes ways to improve quality and throughput
  • Disseminates results to multiple internal stakeholders
  • Writes reports for internal purpose, and if possible external purposes
Qualifications & Skills
  • Successfully completed PhD or equivalent, in the molecular (neuro)biology or related topic (knowledge in the field of neurodegenerative disorders and/or proteinopathies is advantageous)
  • Previous experience in biomarker discovery is highly advantageous
  • Experience with molecular biology and biochemical techniques, including techniques to measure protein expression at high sensitivity (e.g. MSD, Luminex, TR-FRET, Quanterix, SMCxPro)
  • Experience with next-generation sequencing approaches, proteomics and/or metabolomics is a plus
  • Experience with MRI-based methods (volumetric, MRS, PET) and functional CNS measures (fMRI, EEG) is a plus
  • Experience with handling of animal tissues and biofluids for DNA, RNA and protein analysis under Microbiological Safety Level II restrictions
  • Experience with cellular biology techniques (culturing of bacterial and human cells)
  • Animal experience (art. 9 / 12 / 13f Dutch law on animal experimentation) is a plus
  • Hands-on experience in writing, presenting, and reviewing in research documents (reports, patents, publications etc.)
  • Excellent knowledge of the English language (verbal, written and scientific)
  • Pro-active attitude, flexible and professional
  • Excellent presentation and written skills
Core competencies  
  • Outstanding planning and organizational capabilities to plan own workload
  • Proactive attitude with high level of ownership and accountability
  • Enthusiastic team player with strong interpersonal effectiveness and collaboration skills
  • Strong analytical skills
  • Clear communication and presentation skills in project teams and beyond
  • Flexible to act in a highly dynamic and demanding environment
Important note:
  • Interviews are expected to start on the second half of August
 
Please contact Ian Wood, Senior Recruitment Consultant. i.wood@consultseuss.com +31 (0)6 26 65 71 71