Senior Scientist Bioanalytics

Seuss+

the Scientist bioanalytics is responsible for the development, qualification, and validation of biomarker-based analytical methodologies.

  • Biotechnology
  • Scientist
  • Bioanalytics
Senior Scientist Bioanalytics
 
Our client is dedicated to bringing innovative therapies or unmet medical needs to patients. In doing so each function is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) by recognizing the sense of urgency in areas of high medical need.
 
Bioanalytics is a functional group within the Research and Development department. The main responsibility focuses on providing support to Pre-Clinical Research and Development, Clinical development and beyond (MAA/BLA). On the one hand, as part of these supporting activities, bioanalytics is responsible for the development, qualification, validation, and implementation of bio­ analytical methods that are used to monitor product efficacy (biological activity) and product safety. On the other hand, bioanalytics is responsible for performing routine sample analyses and reporting the derived data thereof, using the aforementioned developed/qualified assays as part of Pre-Clinical Research and Development studies.
 
For the evaluation of therapeutic efficacy during Non-/clinical phase, the availability of relevant analytical methodologies which are based on pharmacodynamic biomarkers is essential. However, the establishment of those assays is not trivial. For many indications, and in particular for CNS indications, biomarker-based readout of therapeutic efficacy is made complicated by practical and scientific limitations. These, among others, include scarcity of relevant clinical samples as well as limited understanding of the full molecular pathobiology of disease.
 
Within the bioanalytics team, the Scientist bioanalytics is responsible for the development, qualification, and validation of biomarker-based analytical methodologies for each targeted indication. Establishing these methodologies will require alignment with other departments within research- and preclinical stages all the way to clinical stage. The Scientist will work in close collaboration with all functionalities involved in the development of the company’s gene therapies from proof of concept (PoC) to clinical phase, e.g., research, non-clinical development, and clinical development. In order to succeed the Scientist should have profound understanding of biochemical and bioanalytical methodology and have experience with developing biomarker assays. 
 
Main Purpose of the job
  • To ensure availability (in-house, outsourced or partnered) of the biomarker‑based bioanalytical methodologies.
  • To closely interact with pre- and clinical departments to align on the implementation of the corresponding bioanalytical methodologies.
Qualifications
  • PhD in a life-sciences related field, preferably with focus on CNS indications.
  • Proven scientific background, preferably within a clinical context.
  • Profound understanding of molecular pathobiology, preferably in CNS indications.
  • Affinity with bio-analytical methodologies, preferably in the area of biologics, gene therapy or vaccines.
Competencies
  • Integer: accurate, dependable.
  • Detail oriented: strong analytical skills, scientifically critical mindset.
  • Proactive: Goal-driven with awareness of timelines.
  • Co-operative: ability and drive to work within an interdisciplinary (project) team.
  • Communicative: able to network, able to establish liaisons with external parties, able to liaise between academic and commercial frameworks.